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目的:探讨延胡索对局灶性脑梗死的作用。方法: 总共有30只Sprapue-Dawley(SD)大鼠被用来研究。局灶性脑梗死动物模型的建立是将两侧的颈总动脉和右侧的中大脑动脉的血流阻断90min后,再经24h的灌流,然后评估它们的神经状态。大鼠被牺牲取脑,并作成切片用2,3,5-triphenyl-tetrazoliumchloride染色。以神经的状态和脑梗死面积的变化作为指标来评估延胡索对脑梗死的作用。另外,24只SD大鼠腹腔注射延胡索,经24h后从心脏采血测量血液的变化。结果:延胡索100mg/kg腹腔注射能够改善大鼠神经缺损的症状和减少脑梗死的面积以及能增加全血中红血球的数目和提高血比容(hematocrit)。结论:延胡索在缺血再灌流损伤大鼠能改善神经状态和减少脑梗死面积。
Objective: To investigate the effect of Corydalis on focal cerebral infarction. Methods: A total of 30 Sprapue-Dawley (SD) rats were used for the study. The animal model of focal cerebral infarction was established by blocking the blood flow of the common carotid artery on both sides and the right middle cerebral artery for 90 minutes, then perfused for 24 hours, and then evaluated their neurological status. Rats were sacrificed and sacrificed, and sections were stained with 2,3,5-triphenyl-tetrazolium chloride. The effect of Corydalis on cerebral infarction was evaluated using the changes in the state of the nerve and the area of cerebral infarction as indicators. In addition, 24 SD rats were intraperitoneally injected with Corydalis, and blood was collected from the heart 24 hours later to measure blood changes. RESULTS: Intraperitoneal injection of Corydalis yanhus 100 mg/kg could improve the symptoms of nerve defects in rats and reduce the area of cerebral infarction and increase the number of red blood cells in whole blood and increase the hematocrit. CONCLUSION: Corydalis yanhusuo can improve the nerve status and reduce the cerebral infarct size in rats with ischemia-reperfusion injury.