超氧化物在许多人类疾病,包括高血压的发病中起作用。然而,目前常用的抗氧化剂在众多临床试验中证明无治疗效果,其中的可能性是目前无法有效地将这些抗氧化剂导入产生超氧化物的亚细胞水平。因为线粒体是产生各种活性氧的重要来源,该研究假设清除线粒体内的超氧化物可能产生治 Superoxide plays a role in the pathogenesis of many human diseases, including hypertension. However, the most commonly used antioxidants presently show no therapeutic effect in a large number of clinical trials, with the possibility that it is currently not possible to efficiently introduce these antioxidants into superoxide producing subcellular levels. Because mitochondria are an important source of various reactive oxygen species, the study hypothesized that clearing the mitochondrial superoxide may result in treatment