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帕瑞昔布钠是高选择性的环氧化酶-2(COX-2)抑制剂的前体,可静脉给药和肌肉注射,并迅速转化成具有强效镇痛作用的伐地昔布,并已证明可减少手术患者对阿片类麻醉剂的需要。目前的研究中多将帕瑞昔布钠与吗啡联用。
Parecoxib sodium is a precursor of a highly selective cyclooxygenase-2 (COX-2) inhibitor that can be administered intravenously and intramuscularly and rapidly converted to valdecoxib with potent analgesic action It has been shown to reduce the need for opioid anesthetics in surgical patients. In the current study, parecoxib sodium was used in combination with morphine.