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目的探究鼠神经生长因子联合甲钴胺治疗慢性乙醇中毒性周围神经病临床效果。方法 46例慢性乙醇中毒性周围神经病患者随机分为观察组与对照组,各23例。对照组给予甲钴胺治疗,观察组给予甲钴胺+鼠神经生长因子治疗。对比两组临床效果及感觉神经传导速度(SNCV)、运动神经传导速度(MNCV)变化情况。结果观察组临床治疗总有效率为91.30%,显著高于对照组的65.22%,差异有统计学意义(P<0.05);治疗后观察组SNCV、MNCV均明显高于对照组,差异有统计学意义(P<0.05)。结论鼠神经生长因子联合甲钴胺治疗慢性乙醇中毒性周围神经病临床效果显著,能缓解患者临床症状,改善周围神经功能。
Objective To investigate the clinical effect of rat nerve growth factor combined with mecobalamin in the treatment of chronic ethanol-induced peripheral neuropathy. Methods 46 cases of chronic alcoholism of peripheral neuropathy were randomly divided into observation group and control group, 23 cases each. The control group was treated with mecobalamin, and the observation group was treated with mecobalamin + mouse nerve growth factor. The clinical effects, sensory nerve conduction velocity (SNCV) and motor nerve conduction velocity (MNCV) were compared between the two groups. Results The total effective rate of observation group was 91.30%, which was significantly higher than that of control group (65.22%), the difference was statistically significant (P <0.05). After treatment, SNCV and MNCV in observation group were significantly higher than those in control group Significance (P <0.05). Conclusion The clinical effect of rat NGF combined with mecobalamin in the treatment of chronic alcoholic toxic peripheral neuropathy is significant, which can relieve the clinical symptoms and improve peripheral nerve function.