作者选择7例晚期前列腺癌患者,平均年龄72岁。均未使用影响脂质或脂蛋白代谢的药物。口服酮康唑800mg,每8小时1次。每周复查一次,2周后每月1次,患者饮食习惯不变。至少随访5个月。经酮康唑治疗1周,血浆胆固醇水平降低27％(p<0.001),其中6例持续性降低达5个月之久。5个月后平均胆固醇值降低18％(p<0.005);血浆甘油三酯浓度无变化。30天后, The authors selected 7 patients with advanced prostate cancer, mean age 72 years. None of the drugs that affect lipid or lipoprotein metabolism were used. Oral ketoconazole 800mg, every 8 hours 1. Review once a week, once a month after 2 weeks, the patient’s eating habits unchanged. At least 5 months follow-up. One week after ketoconazole treatment, the plasma cholesterol level was reduced by 27% (p <0.001), of which 6 were consistently decreased by 5 months. After 5 months the average cholesterol value decreased 18% (p <0.005); no change in plasma triglyceride concentration. After 30 days,