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目的探讨神经纤毛蛋白-2(Neuropilin-2,NRP-2)在胃癌组织中的表达及与胃癌的发生、发展及预后的关系。方法回顾性收集152例胃癌患者的临床病理资料及预后情况,采用免疫组化法检测癌组织及相对正常组织NRP-2的表达。分析NRP-2的表达与临床病理及预后之间的关系,评估NRP-2是否可以作为评判胃癌预后的参考指标。结果 1胃癌组织中高表达比率70.4%(107/152),高于相对正常组织7.9%(12/152),(P<0.05)。2NRP-2的表达与肿瘤细胞分化程度、浸润深度、淋巴结转移及TNM分期(P<0.05)有关。3NRP-2高表达患者的生存期差于低表达的患者(中位生存期27个月VS50个月,P<0.05)。4COX比例风险模型进行多因素分析表明NRP-2的表达水平是影响胃癌预后的危险因素(P<0.05)。结论 1NRP-2在胃癌的发生、发展中起到作用,与胃癌的恶性生物学行为相关。2NRP-2高水平表达提示预后不良。3NRP-2有望作为判断胃癌生物学行为和预后的参考指标。
Objective To investigate the expression of Neuropilin-2 (NRP-2) in gastric cancer and its relationship with the occurrence, development and prognosis of gastric cancer. Methods The clinical and pathological data and prognosis of 152 gastric cancer patients were retrospectively collected. The expression of NRP-2 in cancer tissues and normal tissues was detected by immunohistochemistry. The relationship between NRP-2 expression and clinical pathology and prognosis was analyzed to evaluate whether NRP-2 can be used as a reference index to evaluate the prognosis of gastric cancer. Results 1 The high expression rate in gastric cancer tissues was 70.4% (107/152), which was higher than that in the normal tissues (7.9%, 12/152) (P <0.05). The expression of 2NRP-2 was correlated with tumor cell differentiation, depth of invasion, lymph node metastasis and TNM stage (P <0.05). Patients with high 3NRP-2 expression had poorer survival than those with low expression (median survival 27 months vs 50 months, P <0.05). Multivariate analysis showed that the expression of NRP-2 was a risk factor affecting the prognosis of gastric cancer (P <0.05). Conclusion 1NRP-2 plays a role in the occurrence and development of gastric cancer, which is related to the malignant biological behavior of gastric cancer. High levels of 2NRP-2 suggest a poor prognosis. 3NRP-2 is expected to be used as a reference index to judge the biological behavior and prognosis of gastric cancer.