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目的 :探究局部热疗联合外用维A酸和重组人干扰素治疗扁平疣的临床效果和安全性。方法 :选取在本院确诊为扁平疣的患者40例为研究对象,将患者随机分为对照组和观察组,对照组患者的治疗方式为维A酸联合重组人干扰素;观察组患者的治疗方法则在对照组治疗基础上加用局部热疗。对两组进行治疗后对比其效果以及患者药物使用安全情况。结果 :实验结果显示,观察组治疗后其总有效率达到85%,而相比较与观察组,对照组仅为75%。从此数据可见,观察组效果要好于对照组,P<0.05,有统计学差异。另外,观察组的不良反应发生率为10%,对照组不良反应的发生率为15.0%,数据对比结果(P<0.05)为差异无统计学意义。为探究患者预后情况,在患者治疗6个月之后,观察其复发情况,结果发现,观察组复发率(5%)明显低于对照组(15%)。结论 :通过两组对比发现,通过局部热疗联合外用维A酸、重组人干扰素对扁平疣患者进行治疗能有效提升扁平疣的治疗效果,并且具备良好的安全性,值得在临床治疗中得到应用及推广。
Objective: To investigate the clinical effect and safety of local hyperthermia in combination with tretinoin and recombinant human interferon in the treatment of flat warts. Methods: Forty patients with flat warts diagnosed in our hospital were enrolled in this study. The patients were randomly divided into control group and observation group. The control group was treated with Tretinoin combined with recombinant human interferon and observation group Method is based on the control group plus local hyperthermia. After the two groups were treated, the effect and safety of drug use were compared. Results: The experimental results showed that the total effective rate of observation group after treatment reached 85%, while compared with the observation group, the control group was only 75%. As can be seen from this data, the observation group effect is better than the control group, P <0.05, with statistical differences. In addition, the incidence of adverse reactions in the observation group was 10% and the incidence of adverse reactions in the control group was 15.0%. There was no significant difference between the data (P <0.05). To explore the prognosis of patients, the patients were observed for 6 months after the treatment of relapse, the results showed that the observation group recurrence rate (5%) was significantly lower than the control group (15%). Conclusion: Through the comparison of the two groups, we found that the treatment of flat wart with topical hyperthermia combined with retinyltransferase and recombinant human interferon can effectively improve the treatment effect of flat wart, and has good safety, which is worth to be obtained in clinical treatment Application and promotion.