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目的观察比较埃索美拉唑和奥美拉唑治疗反流性食管炎的疗效和安全性。方法84例经胃镜确诊的反流性食管炎患者,随机分为治疗组和对照组。治疗组42例,应用埃索美拉唑40mg,1次/d;对照组42例,应用奥美拉唑40mg,1次/d,疗程均为4周。主要观察临床疗效、主要症状平均缓解时间、内镜积分变化及不良反应。结果2周末和4周末显效率分别为,治疗组59.5%、83.3%;对照组31.0%、54.8%。2组比较,差异有统计学意义(χ2=6.92、8.02,P<0.01)。2组主要症状平均消失时间及内镜积分变化比较,差异有统计学意义(t=3.21、3.46,P<0.01)。结论埃索美拉唑治疗反流性食管炎疗效显著,能迅速改善症状,安全性好。
Objective To compare the efficacy and safety of esomeprazole and omeprazole in the treatment of reflux esophagitis. Methods 84 cases of reflux esophagitis diagnosed by gastroscope were randomly divided into treatment group and control group. Treatment group 42 cases, the application of esomeprazole 40mg, 1 / d; control group of 42 cases, the application of omeprazole 40mg, 1 / d, treatment were 4 weeks. The main observation of clinical efficacy, the average time to alleviate the main symptoms, endoscopic changes and adverse reactions. Results The effective rates at 2 and 4 weeks were 59.5% and 83.3% in the treatment group and 31.0% and 54.8% in the control group respectively. The difference between the two groups was statistically significant (χ2 = 6.92, 8.02, P <0.01). There were significant differences in mean disappearance time and endoscopic score between the two groups (t = 3.21, 3.46, P <0.01). Conclusion Esomeprazole treatment of reflux esophagitis significant effect, can quickly improve the symptoms, good safety.