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目的探讨镍铬合金修复体对患者牙龈组织的致癌性.方法选择行镍铬合金冠/桥修复固定义齿2~5年的患者30例,取镍铬修复体患者牙龈组织.并以正常人群牙龈组织做对照.检测牙龈组织中Survivin蛋白的表达.结果镍铬修复体患者牙龈组织中Survivin蛋白的表达与正常牙龈组织无显著性差异(P>0.05)。结论镍铬合金对牙龈组织无明显或潜在致癌性。
Objective To investigate the carcinogenicity of nichrome prosthesis on the gingival tissue of patients.Methods 30 patients with nichrome crowns / bridges with fixed dentures of 2 to 5 years were selected, and the gingival tissues of patients with nickel-chromium restoration were obtained.At the same time, The expression of Survivin protein in gingival tissues was measured.Results The expression of Survivin protein in gingival tissues was not significantly different from that in normal gingival tissues (P> 0.05). Conclusion Ni-Cr alloy has no obvious or potential carcinogenicity on gingival tissues.