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目的探讨显微镜结肠炎(MC)发病机制中免疫因素和炎症因子所起的作用。方法对2004年8月至2006年3月就诊于包头医学院第二附属医院内蒙古消化病研究所的32例MC患者、71例肠易激综合征(IBS)及38例溃疡性结肠炎(UC)患者,采用免疫组织化学法检测肠黏膜IgG、IgM,采用放射免疫法测定血清IL-8质量浓度。结果MC组肠黏膜IgG、IgM表达显著增高,与IBS组比较差异有统计学意义(P<0.05),与UC组比较差异无统计学意义。MC组血清IL-8显著低于UC组(P<0.05),与IBS组比较差异无统计学意义。结论在MC的发病机制中,免疫调节功能异常可能为MC发病的主要因素,炎症并非引起MC的主要原因。
Objective To investigate the role of immune factors and inflammatory cytokines in the pathogenesis of microscopic colitis (MC). Methods From August 2004 to March 2006, 32 cases of MC patients, 71 cases of irritable bowel syndrome (IBS) and 38 cases of ulcerative colitis (UC) were referred to the Institute of Digestive Diseases, the Second Affiliated Hospital of Baotou Medical College. ) Patients, immunohistochemical detection of intestinal mucosal IgG, IgM, radioimmunoassay determination of serum IL-8 concentration. Results The expressions of IgG and IgM in intestinal mucosa of MC group were significantly higher than those of IBS group (P <0.05), but there was no significant difference between UC group and MC group. The level of IL-8 in MC group was significantly lower than that in UC group (P <0.05), but there was no significant difference with IBS group. Conclusion In the pathogenesis of MC, abnormal immune regulation may be the main factor for the pathogenesis of MC. Inflammation is not the main cause of MC.