环氧合酶-2(cyclooxygenase-2,COX-2)是前列腺素合成过程中的限速酶,参与炎症、发热等病理生理过程。近几年来,流行病学、动物学实验等多方面的证据表明,COX-2与恶性肿瘤的发生和转移密切有关,而且非甾体类抗炎药物通过抑制COX-2的表达而具有防治肿瘤的作用〔1,2〕。E-钙黏素是 Cyclooxygenase-2 (COX-2) is the rate-limiting enzyme in prostaglandin synthesis and is involved in pathophysiological processes such as inflammation and fever. In recent years, epidemiology, animal experiments and other aspects of the evidence that COX-2 and malignant tumor is closely related to the occurrence and metastasis, and non-steroidal anti-inflammatory drugs by inhibiting the expression of COX-2 with the prevention and treatment of cancer The role of [1,2]. E-cadherin is