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目的探讨严重急性呼吸综合征(SARS)患者肾内免疫细胞的免疫组织化学变化并对其作用进行分析。方法应用免疫组织化学方法显示6例SARS死亡患者和3例意外死亡者肾内免疫细胞,进行其形态观察,并采用图像分析系统进行定量分析。结果6例SARS患者肾内CD68+单核/巨噬细胞显著增多(P<0.05),CD3+T细胞、CD20+B细胞和S-100+树突状细胞与对照组无差别(P>0.05)。结论SARS患者肾内单核/巨噬细胞为主要免疫应答细胞,提示单核/巨噬细胞在SARS肾病变中起着重要作用。而T细胞、B细胞以及树突状细胞可能受到SARS冠状病毒的攻击,其功能可能遭到破坏。
Objective To investigate the immunohistochemical changes of intrarenal immune cells in patients with severe acute respiratory syndrome (SARS) and analyze their effects. Methods Six cases of SARS death and three cases of accidental death were detected by immunohistochemistry. The morphological changes were observed and quantified by image analysis system. Results The CD68 + monocytes / macrophages in the kidney were significantly increased in 6 patients with SARS (P <0.05). There was no difference between CD3 + T cells, CD20 + B cells and S-100 + dendritic cells in control group . Conclusion Renal monocytes / macrophages in SARS patients are the major immune response cells, suggesting that monocytes / macrophages play an important role in SARS nephropathy. However, T cells, B cells and dendritic cells may be attacked by the SARS coronavirus and their function may be disrupted.