目前对干扰素治疗丙型肝炎治疗反应的判断仍以血清ALT水平是否正常做为判定指标。虽然血清中的丙型肝炎病毒核酸(HCV RNA)清除率是干扰素治疗结果较好的评价指标,但由于HCV RNA的检测需要PCR等技术,因而没有得到广泛的应用。本研究的目的就是通过血清补体冷激活(低温保存的血清丧失溶血活性的现象)测定来评价患者对干扰素治疗后HCV RNA滴度的变化以及HCV携带者病毒血症的变化。 At present, the judgment of response to interferon treatment of hepatitis C is still the determination of whether the serum ALT level is normal. Although the clearance of HCV RNA in serum is a good indicator of the result of interferon treatment, the detection of HCV RNA is not widely used because of the need of PCR and other technologies. The aim of this study was to evaluate patients’ changes in HCV RNA titer after interferon treatment and changes in HCV carrier viremia by serum complement cold-activation (phenomenon of loss of hemolytic activity of cryo-preserved serum).