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目的: 观察喷他佐辛对全麻上肢手术苏醒期躁动的影响.方法: 全麻下行择期上肢手术患者60例随机分为两组.Ⅰ组(观察组, n=30)患者在手术结束缝皮前以喷他佐辛0.25 mg·kg-1稀释至10ml缓慢静注(超过3 min);Ⅱ组(对照组, n=30)在手术结束缝皮前以同样速度静注0.9%氯化钠注射液10 ml.监测比较两组患者诱导前(T0)、拔管前(T1)、拔管即刻(T2)、拔管后5 min(T3)、拔管后10 min(T4)、拔管后15 min(T5)等时点的血压、心率变化;比较两组患者的苏醒时间、拔管时间,拔管后15 min的躁动情况和躁动评分,以及患者恶心呕吐发生情况等.结果: Ⅱ组在T3~T5时点血压、心率明显高于Ⅰ组(P＜0.05);两组间苏醒时间和拔管时间差异无统计学意义(P＞0.05);Ⅰ组患者拔管后15 min躁动情况和躁动评分均明显低于Ⅱ组(P＜0.05),Ⅰ组患者恶心呕吐发生率和严重程度明显高于Ⅱ组(P＜0.05).结论: 在缝皮前应用喷他佐辛0.25 mg·kg-1可维持拔管时患者循环稳定,减少全麻苏醒期躁动发生,使患者安全、舒适地度过苏醒期.“,”Objective: To observe the effects of pentazocine on emergence agitation.Methods: Totally 60 patients with scheduled upper limb operation with general anesthesia were randomly divided into two groups (n =30).Group Ⅰ was given pentazocine 0.25 mg·kg-1 (diluted to 10ml) and group Ⅱ was treated with 0.9% sodium chloride (10 ml) and both were with slow intravenous injection above 3 min before the surgical stitching.BP and HR were recorded and compared before the induction (T 0), before the extubation (T 1) ,at the extubation (T 2), and 5, 10 and in 15 minutes after the extubation (T 3 , T 4 and T 5).The time of recovery, time of extubation and agitation scores in 15 min after the extubation were recorded and compared, and nausea and vomiting were observed as well in both groups.Results: Compared with those in group Ⅰ, HR and BP in group Ⅱ were significantly higher (P＜0.05) at T 3 , T 4 and T 5.There were no significant differences in the breathing recovery time and awakening time between the groups (P＞0.05).The restlessness score in group Ⅰ was significantly lower than that in groupⅡ (P＜0.05).The incidence and degree of postoperative nausea and vomiting in groupⅠ were significantly higher than those in group Ⅱ (P＜0.05).Conclusion: Pentazocine (0.25 mg·kg-1) given before stitching can maintain stable circulation, reduce emergence agitation and protect the safety of patients.