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目的:观察干扰素α-2b栓联合复方沙棘籽油栓治疗慢性宫颈炎伴高危型乳头瘤病毒(HPV)感染临床疗效。方法:92例慢性宫颈炎伴高危型HPV感染患者,随机分为中西医组和西医组,各46例。西医组予以干扰素α-2b栓阴道给药,月经期停药。中西医组予以干扰素α-2b栓联合复方沙棘籽油栓,交替阴道用药。2组均治疗3月。判断并评估2组治疗3月后临床效果,并比较治疗后随访半年和1年后HPV的转阴率。结果:临床总有效率中西医组95.65%,西医组82.61%,2组比较,差异有统计学意义(P<0.05)。对有效病例随访半年和1年,中西医组HPV转阴率分别为90.91%和77.27%,均明显高于西医组的73.68%和55.26%,2组比较,差异有统计学意义(P<0.05)。结论:干扰素α-2b栓联合复方沙棘籽油栓治疗慢性宫颈炎伴高危型HPV感染临床疗效显著,能有效地清除HPV感染。
Objective: To observe the clinical efficacy of interferon α-2b combined with compound sea buckthorn seed oil suppository in the treatment of chronic cervicitis complicated with high-risk papillomavirus (HPV) infection. Methods: Ninety-two patients with chronic cervicitis complicated with high-risk HPV infection were randomly divided into Western and Western medicine groups (n = 46). Western medicine group to interferon α-2b suppository vaginal delivery, menstrual period withdrawal. Western medicine group to interferon α-2b bolt combined with compound seabuckthorn seed oil suppository, alternating vaginal medication. 2 groups were treated for 3 months. To judge and evaluate the clinical effect of the two groups after 3 months of treatment, and compare the negative conversion rate of HPV after 6 months and 1 year after treatment. Results: The total clinical effective rate was 95.65% in Western medicine group and 82.61% in Western medicine group. There was significant difference between the two groups (P <0.05). The effective rates of HPV negative conversion in Chinese and Western medicine groups were 90.91% and 77.27%, respectively, which were significantly higher than those in Western medicine group (73.68% and 55.26%, respectively) for six months and one year follow-up. There was significant difference between the two groups (P <0.05 ). Conclusion: Interferon α-2b suppository combined with compound seabuckthorn seed oil suppository in the treatment of chronic cervicitis with high-risk HPV infection has significant curative effect and effectively eradicates HPV infection.