Objective:In the present study,spinal metastatic tumors,brucellar spondylids and spinal tuberculosis were quantitatively analyzed using dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) to assess the value of DCE-MRI in the differential diagnosis of these diseases.Methods:Patients with brucellar spondylids,spinal tuberculosis or a spinal metastatic tumor (30 cases of each)received conventional MRI and DCE-MRI examination.The volume transfer constant (Ktrans),rate constant (Kep),extravascular extracelhlar volume fraction (Ve) and plasma volume fraction (Vp) of the diseased vertebral bodies were measured on the perfusion parameter map,and the differences in these parameters between the patients were compared.Results:For pathological vertebrae in cases of spinal metastatic tumor,brucellar spondylitis and spinal tuberculosis,respectively,the Ktrans values (median ± quartile pitch) were 0.989±0.014,0.720±0.01 1 and 0.317±0.005 min-1;the Kep values were 2.898±0.055,1.327±0.017 and 0.748±0.006 min-1;the Ve values were 0.339±0.008,0.542±0.013 and 0.428±0.018;the Vp values were 0.048±0.008,0.035±0.004 and 0.028±0.009;the corresponding H values were 50.25 (for Ktrans,52.47 (for Kep),48.33 (for Ve) and 46.56 (for Vp),and all differences were statistically significant (two-sided P＜0.05).Conclusions:The quantitative analysis of DCE-MRI has a certain value in the differential diagnosis of spinal metastatic tumor,brucellar spondylitis and spinal tuberculosis.