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真核细胞端粒ＤＮＡ序列的丢失与细胞的衰老及凋亡有关． 端粒酶的激活可维持端粒长度并使细胞获得无限增殖的能力． 端粒结合蛋白则可能通过调节端粒酶或其他相关因子的行为参与对端粒长度的调控． 近年有关端粒结合蛋白的研究取得了突破性进展并在此基础上建立了端粒长度调控模型．
The loss of eukaryotic telomere DNA sequence is associated with cell senescence and apoptosis. Activation of telomerase maintains telomere length and allows cells to proliferate indefinitely. Telomere binding proteins may participate in the regulation of telomere length by regulating telomerase or other related factors. In recent years, breakthroughs have been made in the research of telomere binding protein and a telomere length regulation model has been established.