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目的观察急性发作期慢性阻塞性肺疾病(Acute exacerbations of chronic obstructive pulmonary disease,AECOPD)患者治疗前后肺功能及细胞因子的变化。方法采用酶联免疫吸附法(ELISA)测定70例慢性阻塞性肺疾病急性发作期患者入院初及治疗后血清中的白细胞介素-2(IL-2)、肿瘤坏死因子-α(TNF-α)水平,并同时进行肺功能(FEV1%、FEV1/FVC、MVV、MMEF、FEF50、FEF75)测定。结果①治疗后FEV1%、FEV1/FVC、MMEF、FEF50、FEF25、MVV均较治疗前明显改善。②治疗后TNF-α浓度明显下降,IL-2浓度明显升高。结论常规治疗可明显改善气道阻力及肺的通气功能,使TNF-α浓度明显下降,IL-2浓度明显升高。
Objective To observe the changes of lung function and cytokines in patients with acute exacerbations of chronic obstructive pulmonary disease (AECOPD) before and after treatment. Methods The levels of interleukin-2 (IL-2), tumor necrosis factor-α (TNF-α) in sera of 70 patients with acute exacerbation of chronic obstructive pulmonary disease admitted to hospital and after treatment were measured by enzyme-linked immunosorbent assay (ELISA) ), And lung function (FEV1%, FEV1 / FVC, MVV, MMEF, FEF50, FEF75) was measured simultaneously. Results ① After treatment, FEV1%, FEV1 / FVC, MMEF, FEF50, FEF25, MVV were significantly improved compared with those before treatment. ② TNF-α concentration decreased significantly after treatment, IL-2 concentration was significantly increased. Conclusion Conventional treatment can significantly improve airway resistance and lung ventilation function, TNF-α concentration decreased significantly, IL-2 concentration was significantly increased.