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目的探讨冠状动脉粥样硬化心脏病(CHD)与C反应蛋白(CRP)之间的关系。方法测定50例正常对照人群和80例经冠状动脉造影证实为CHD患者血浆的CRP水平,其中单支病变30例、双支病变25例、三支病变25例;稳定型心绞痛31例、不稳定型心绞痛25例,急性心肌梗死24例。结果CRP水平在稳定型心绞痛组、不稳定型心绞痛组、急性心肌梗死组依次增高;稳定型心绞痛组(F=1.826,P<0.05)、不稳定型心绞痛组(F=4.232,P<0.01)及急性心肌梗死组(F=6.745,P<0.01)的CRP水平均明显高于对照组,在冠心病组中,双支病变组(F=7.925,P<0.01)以及三支病变组(F=9.467,P<0.01)中CRP水平也明显高于对照组。结论CRP水平与冠心病和冠脉病变程度相关。
Objective To investigate the relationship between coronary heart disease (CHD) and C-reactive protein (CRP). Methods 50 cases of normal controls and 80 cases of coronary artery angiography confirmed CHD patients with plasma CRP levels, including 30 cases of single-vessel disease, double-vessel disease in 25 cases, three lesions in 25 cases; 31 cases of unstable angina, unstable 25 cases of angina pectoris, 24 cases of acute myocardial infarction. Results The levels of CRP in stable angina group, unstable angina pectoris group and acute myocardial infarction group were higher than those in stable angina group (F = 1.826, P <0.05), unstable angina pectoris group (F = 4.232, P <0.01) (F = 6.745, P <0.01) were significantly higher than those in the control group. There was no significant difference between the two groups (F = 7.925, P <0.01) = 9.467, P <0.01) CRP levels were also significantly higher than the control group. Conclusion The level of CRP is related to the degree of coronary heart disease and coronary artery disease.