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目的 探讨冠心病患者Toll样受体（tolllike receptors，TLR）4水平与冠状动脉（冠脉）病变严重程度的相关性。方法 选取我科住院经冠状动脉造影确诊为冠心病的患者141例。采用Syntax评分反映冠脉病变严重程度，根据Syntax评分结果分为低分(0~22分)61例、中分(23~32分)41例和高分(≥33分)39例。据此分为2组：Syntax低中分组(n=102)，Syntax高分组(n=39)。通过线性相关分析确定TLR4水平与冠脉病变严重程度的关系，通过多因素Logistic回归分析确定冠脉病变的相关因素。结果 与低中分组比较，高分组TLR4水平明显升高〔(93±24) vs.(128±29) ng/ml，P<0.01〕。TLR4水平与Syntax评分呈正相关(r=0.539,P<0.01)。多因素回归分析显示，TLR4水平是Syntax评分≥33分的相关因素(OR=15.645，95%CI：5.322-45.994；P<0.01）。结论 TLR4与冠脉病变严重程度密切相关，随着TLR4水平升高，冠脉病变越严重。
Objective To investigate the relationship between tollkelement receptor 4 (TLR) 4 and the severity of coronary artery (coronary artery) in patients with coronary heart disease. Methods Select 141 cases of coronary heart disease confirmed by coronary angiography in our hospital. Syntax scores reflect the severity of coronary lesions, according to the Syntax score was divided into low score (0 to 22 points) in 61 cases, 41 points (23 to 32 points) and high score (39 points). Divided into two groups: Syntax low grouping (n = 102), Syntax high grouping (n = 39). The relationship between the level of TLR4 and the severity of coronary lesion was determined by linear correlation analysis, and the related factors of coronary lesion were determined by multivariate Logistic regression analysis. Results Compared with the low and middle groups, the level of TLR4 in the high-grade group was significantly higher 〔(93 ± 24) vs. (128 ± 29) ng / ml, P <0.01〕. The level of TLR4 was positively correlated with Syntax score (r = 0.539, P <0.01). Multivariate regression analysis showed that TLR4 levels correlated with a Syntax score ≥33 points (OR = 15.645, 95% CI: 5.322-45.994; P & lt; 0.01). Conclusion TLR4 is closely related to the severity of coronary artery disease. As the level of TLR4 increases, the severity of coronary artery disease becomes more serious.