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复发转移是恶性肿瘤死亡的主要原因,发现高灵敏、特异的肿瘤标记物和提高复发转移的预测是检验医学面临的亟待解决的问题。肿瘤通过血循环复发转移时,脱落至外周血的肿瘤细胞、肿瘤组织代谢及机体的抗肿瘤反应产物(核苷酸、蛋白)促外周血发生特异的表达谱改变;相应的检测技术应运而生并不断发展。现对复发转移相关的循环肿瘤细胞、循环血游离核苷酸及蛋白多肽谱及其检测技术的进展作一综述。
Recurrence and metastasis are the main causes of death from malignant tumors. It is an urgent problem to be solved to find highly sensitive and specific tumor markers and to improve the prognosis of recurrence and metastasis. Tumor metastasis through the blood circulation, shedding to the peripheral blood of tumor cells, tumor tissue metabolism and the body’s anti-tumor response products (nucleotides, proteins) to promote peripheral blood specific expression changes; the corresponding detection technology came into being Growing. Now the recurrence and metastasis-related circulating tumor cells, circulating blood free nucleotide and protein peptide profile and its detection technology are reviewed.