目的探讨阿托伐他汀钙对颈动脉粥样硬化患者的治疗作用。方法选择2009年5至2010年5月我院收治的90例住院的缺血性脑血管病患者。随机分为观察组和对照组,每组各45例,所有患者均给予抗血小板,控制血压、血糖等。观察组同时口服阿托伐他汀钙20mg/d,对照组同时加用安慰剂治疗6个月。结果观察组在使用辛伐他汀钙治疗6个月后TC、TG、LDL水平与同组治疗前比较显著下降(P均<0.05),HDL水平与同组治疗前比较明显升高(P<0.05);对照组治疗前后IMT和Crouse斑块积分与观察组治疗前后差值比较,明显增加,差异有统计学意义(P<0.05)。结论阿托伐他汀钙可以降低颈动脉粥样硬化患者血脂水平,稳定斑块,减缓动脉硬化速度,对预防脑血管事件的发生有一定作用。 Objective To investigate the therapeutic effect of atorvastatin calcium on patients with carotid atherosclerosis. Methods From May 2009 to May 2010 in our hospital admitted 90 cases of ischemic cerebrovascular disease patients. Randomly divided into observation group and control group, 45 cases in each group, all patients were given anti-platelet, blood pressure control, blood sugar and so on. In the observation group, atorvastatin calcium 20 mg / d was orally administered at the same time. The control group was also treated with placebo for 6 months. Results The levels of TC, TG and LDL in the observation group after 6 months of treatment with simvastatin decreased significantly (P <0.05), while the levels of HDL in the observation group were significantly higher than those before treatment (P <0.05 ); Before and after treatment, IMT and Crouse plaque score in the control group were significantly increased compared with those in the observation group before and after treatment, the difference was statistically significant (P <0.05). Conclusions Atorvastatin calcium can reduce the level of blood lipid, stabilize the plaque and slow the rate of atherosclerosis in patients with carotid atherosclerosis, and play a role in preventing the occurrence of cerebrovascular events.