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短暂的心肌缺血可使心肌能耐受其后较长时间缺血,本文观察是否远处其它器官短暂缺血也能保护心肌。方法:心肌缺血预处理组(IPC),3次短暂心肌缺血,每次5min,其间间隔5min;肠系膜动脉阻塞组(MAO),MAO15min,放松10min;股动脉阻塞组(FAO);股动脉结扎15min,放松10min。其后三组均阻塞在冠状动脉主干血流90min,再灌注180min后将鼠杀死,用TTC染色、观察坏死心肌的范围。结果:MAO组、FAO组、心肌IPC组与假手术组相比心肌坏处面积明显缩小(P<0.01).而前三组间心肌坏处面积则无显著性差异(P>0.05)。结论:短暂的肠系膜动脉、股动脉阻塞和心肌缺血预处理一样能有效保护心肌组织被长时间缺血,再灌注的损伤。
Short-term myocardial ischemia can make the myocardium to withstand a longer period of ischemia, this article to observe whether other organs in the distance transient ischemia can also protect the myocardium. Methods: Myocardial ischemic preconditioning (IPC) group was treated with three short-term myocardial ischemia (5 min each) with an interval of 5 min, MAO, MAO for 15 min, relaxation for 10 min, femoral artery occlusion (FAO) Ligation 15min, relax 10min. After three groups were blocked in the coronary artery blood flow 90min, 180min after reperfusion, the mice were killed, stained with TTC to observe the extent of necrotic myocardium. Results: Compared with the sham operation group, myocardial infarction size was significantly reduced in the MAO group, the FAO group and the myocardial IPC group (P <0.01). There was no significant difference in the area of myocardial damage among the first three groups (P> 0.05). Conclusions: Short-term mesenteric artery, femoral artery occlusion and myocardial ischemic preconditioning can effectively protect myocardium from long-term ischemia and reperfusion injury.