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目的：观察靶控输注异丙酚复合瑞芬太尼用于腹腔镜手术麻醉的临床效果。方法选择ASA Ⅰ～Ⅱ级120例行腹腔镜手术麻醉患者，随机分为A组和B组，各60例。 A组行靶控输注麻醉，B组行复合静脉麻醉，2组全麻诱导前均先开放静脉输液。比较2组各时间点心率、收缩压、舒张压水平变化，以及术后自主呼吸、呼唤睁眼和自主呼吸达到平稳时间，并统计2组术中知晓率。结果2组患者的心率、血压基础值比较，差异无统计学意义（P＞0．05）。诱导、气管内插管后，A组的心率、血压与基础值相比较，变化不明显，差异均无统计学意义（P＞0．05）；B组的心率、血压与基础值比较变化明显，差异均有统计学意义（P＜0．05）。麻醉后，A组至自主呼吸恢复、呼唤睁眼、自主呼吸达到平稳所需的时间均明显短于B组，差异均有统计学意义（ P＜0．05）。 A组术中知晓率为1．7％（1／60）明显低于B组的8．3％（5／60），差异有统计学意义（P＜0．05）。结论异丙酚复合瑞芬太尼靶控输注用于腹腔镜手术的麻醉过程中，血流动力学较稳定、术后清醒快、拔管早、恢复快、术后并发症少。“,”Objective To observe clinical efficacy of composite propofol and remifentanil for target -controlled infusion during laparoscopic surgery anesthesia .Methods 120 patients(ASAⅠ~Ⅱ) who underwent laparoscopic surgery were ran-domly divided into group A and group B ,with 60 cases of each .Before general anesthesia inducing ,both of the two groups open the intravenous infusion .Group A received target controlled infusion ,and group B received composite intravenous anesthesia . heart rate,systolic blood pressure,diastolic blood pressure levels and recovery time ,Intraoperative awareness rate between the two groups were compared .Results There was no significant difference in heart rate and blood pressure between the 2 groups (P>0.05).After induction and endotracheal intubation ,compared with the basic values ,the heart rate and blood pressure of group A had no significant change (P>0.05),and heart rate and blood pressure changes in the group B ,the differences were statistically significant(P<0.05).The time of spontaneous breathing recovery ,call up and breathing smoothly of group A were significantly shorter in the group B,the differences were statistically significant (P<0.05).Intraoperative awareness rate of group A(1.7%,1/60) was lower than that of group B(8.3%,5/60),the difference was statistically significant(P<0.05). Conclusion Propofol combined with remifentanil for target controlled infusion in laparoscopic operation ,and the patients are conscious fast ,early extubation ,fast recovery and have less complications .