原发性肝癌(primary hepatocellular carcinoma,PHC)是我国常见的恶性肿瘤,占所有癌症的4%,其发病率和死亡率有逐年增高的趋势。对PHC的早期诊断和鉴别诊断一直是阻碍临床和研究的一大难题。甲胎蛋白(alpha-fetoprotein,AFP)多年来被作为诊断PHC的首选指标,使原发性肝癌得以早期诊断。随着科学技术的进展,肿瘤标志物的种类已扩展到包括蛋白类及基因类的标志物。本文就原发性肝癌肿瘤标志物的研究 Primary hepatocellular carcinoma (PHC) is a common malignant tumor in our country, accounting for 4% of all cancers. The incidence and mortality of PHC have been increasing year by year. The early diagnosis and differential diagnosis of PHC has been a major obstacle to clinical and research. Alpha-fetoprotein (AFP) has been the first choice for the diagnosis of PHC for many years, so that primary liver cancer can be diagnosed early. With the progress of science and technology, the types of tumor markers have been extended to include markers of proteins and genes. This article on the primary liver cancer tumor markers