自1978年WHO将甲硝唑选为抗厌氧菌的基本药物后,已在临床各科中广泛应用。它具有疗效高、疗程短、使用方便、经济及药源丰富等优点。有的医生往往只注重其临床疗效,忽略了它的毒副作用。笔者综合有关文献,对此作如下介绍。1 毒副作用1.1 消化系统不良反应 为其最常见的副作用。陈振东报道,消化系统反应发生率为 54.3％,其中腹痛发生率为10％,其次为恶心、呕吐、腹泻,口腔炎等,这些反应均发生在用药1～3d。用药同时 Since 1978, WHO selected metronidazole as an anti-anaerobic essential drugs, has been widely used in clinical subjects. It has high efficacy, short course, easy to use, economical and rich source of medicine and so on. Some doctors tend to focus only on its clinical efficacy, ignoring its toxic side effects. I synthesize the relevant literature, which is described below. 1 side effects 1.1 digestive system adverse reactions as its most common side effects. Chen Zhendong reported that the incidence of digestive system reaction was 54.3%, of which the incidence of abdominal pain was 10%, followed by nausea, vomiting, diarrhea, stomatitis, etc., these reactions occurred in medication 1 ~ 3d. At the same time medication