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目的验证鼻咽癌的癌基因表达与鼻咽癌生长倾向和放射敏感性的关系。方法检测我院６１例鼻咽癌病人的Ｐ５３、Ｐ２１、ＮＭ２３、ＰＣＮＡ，并分析鼻咽癌病人临床肿瘤生长方式和放射治疗结果。结果鼻咽癌上行性生长者Ｐ５３、Ｐ２１、ＮＭ２３阳性率较高，而ＰＣＮＡ阳性率较低。在Ｐ５３、Ｐ２１、ＮＭ２３三项里鼻咽癌上行性、混合性与下行性三种生长方式间存在明显的梯度变化。Ｐ５３、ＰＣＮＡ在放疗５０Ｇｙ肿物就消退时，阳性率低于肿瘤未消退者，而Ｐ２１、ＮＭ２３变化不大。结论从基因水平证实鼻咽癌生长方式确实存在上、下行两种倾向。另外本文资料还表明Ｐ５３、ＰＣＮＡ与放射敏感性有关，Ｐ２１、ＮＭ２３与放射敏感性关系不明显。
Objective To verify the relationship between oncogene expression in nasopharyngeal carcinoma and nasopharyngeal carcinoma growth tendency and radiosensitivity. Methods The P53, P21, NM23 and PCNA of 61 patients with nasopharyngeal carcinoma in our hospital were detected, and the clinical tumor growth pattern and radiotherapy results of patients with nasopharyngeal carcinoma were analyzed. Results The positive rates of P53, P21 and NM23 in nasopharyngeal carcinoma were higher, but the positive rate of PCNA was lower. In P53, P21, NM23 three nasopharyngeal carcinoma upward, mixed and downward three kinds of growth patterns exist obvious gradient changes. P53, PCNA in radiotherapy 50Gy tumor subsided, the positive rate was lower than the tumor did not subside, and P21, NM23 little change. Conclusion It is confirmed that there are two kinds of upward and downward tendencies in the growth pattern of nasopharyngeal carcinoma at the gene level. In addition, this data also shows that P53, PCNA and radiation sensitivity, P21, NM23 and radiation sensitivity is not obvious.