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測定黄連中小蘗碱含量的方法很多,这里就常見的一些方法略予評述。中国药典1953年版第一增补本(1957)和日本药局方的方法相同,都是在含黃連生物碱的水溶液中加碘化鉀溶液,使小蘗碱成碘氫酸盐沉淀而析出,然后将沉淀悬浮在水中,加入丙酮,使小蘗碱成为丙酮小蘗碱沉淀,过滤,干燥,而后称重。但是根据文献可知,不但小蘗碱能与碘化鉀形成沉淀,并且結构与小蘗碱类似的生物碱(如黄連中的palmatine,jatrorrhizine 和columbamine等)以及甚至結构不同的其他季胺化合物也能发生沉淀。再者,与小蘗碱
There are many ways to determine the content of berberine in Coptis chinensis. Here are some common methods to review. The first supplement of the 1953 Chinese Pharmacopoeia (1957) is the same as that of the Japanese Pharmacopoeia. Both of them add potassium iodide solution to the aqueous solution containing alkaloids, so that berberine precipitates as iodide and precipitates, and then precipitates. Suspended in water, acetone was added to precipitate berberine as acetone berberine, filtered, dried, and weighed. However, according to the literature, not only berberine can form a precipitate with potassium iodide, but alkaloids with similar structure to berberine (such as palmatine, jatrorrhizine and columbamine in berberine, etc.) and even other quaternary amine compounds with different structures can also precipitate. . Again, with berberine