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强直性脊柱炎(ankylosing spondylitis,AS)是一种病因不明的慢性炎性疾病。早期主要累及骶髂关节,逐步累及中轴骨骼(脊柱),亦可累及外周关节[1、2]。AS的自然史是指在整个发展过程中,不受任何临床干预,包括各种非手术治疗和手术治疗情况下的自然发展过程。但大多数AS患者在炎性疼痛时已接受各种治疗,很少有患者病程中未得到任何干预。因此,有关AS的自然史报道多为回顾性
Ankylosing spondylitis (AS) is a chronic inflammatory disease of unknown etiology. The main involvement of the early sacroiliac joints, gradually involving the central axis of the skeleton (spine), can also affect the peripheral joints [1,2]. Natural history of AS refers to the natural development process in the whole development process without any clinical intervention, including various non-surgical treatment and surgical treatment. However, most patients with AS have received various treatments for inflammatory pain and few patients have received no treatment during their course of disease. Therefore, the natural history of AS reports mostly retrospective