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为了了解肾动脉成形术前后血管局部血小板功能变化情况,在肾动脉狭窄犬模型上,对9只犬于成形术前后分别测试血管局部血小板粘附、聚集和释放功能指标,并进行比较。结果显示,9只犬在术后测得的肾动脉成形术局部血小板功能值为:血小板粘附率为(49.63±13.02)％,胶原诱导及ADP诱导的血小板聚集率为(44.66±11.70)％及(40.74±17.73)％,T/P比值为2.12±1.03,5-HT释放量为(16.81±2.33)mg/L,GMP-140释放量为(25.44±9.86)mg/L,分别高于术前相应指标数值(36.36±13.82)％,(32.07±13.91)％,(31.84±14.72)％,1.42±0.42,(11.71±4.29)mg/L及(16.49±6.83)mg/L(均P<0.05)。结果表明,伴随成形术产生的血管损伤最终导致血小板功能活化,可能是术后再狭窄形成的重要因素。
In order to understand the changes of local platelet function before and after angioplasty, we measured the local platelet adhesion, aggregation and release function indexes of nine dogs before and after angioplasty in canine renal artery stenosis. The results showed that the values of platelet function of the renal artery angioplasty in nine dogs were: platelet adhesion rate (49.63 ± 13.02)%, collagen induction and ADP-induced platelet aggregation rate (44.66 ± 11.70)%, (40.74 ± 17.73)%, the T / P ratio was 2.12 ± 1.03, the release of 5-HT was (16.81 ± 2.33) mg / L and the release of GMP-140 was (25.44 ± 9.86) mg / L, (36.36 ± 13.82)%, (32.07 ± 13.91)%, (31.84 ± 14.72)%, 1.42 ± 0.42, (11.71 ± 4.29) mg / L and (16.49 ± 6.83) mg / L preoperatively <0.05). The results show that vascular injury associated with angioplasty eventually leads to platelet activation, which may be an important factor in the formation of postoperative restenosis.