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目的:探讨99Tcm-HL91乏氧显像对肺癌与肺转移瘤诊断的可行性及其效果。方法:选择6例正常志愿者进行99Tcm-HL91全身显像,28例肺部原发与继发恶性肿瘤与肿瘤可疑的病人进行胸部99Tcm-HL91乏氧显像,采用1、2、4小时多时相静态显像结合静脉注射显像剂后4小时SPECT/CT断层显像。结果:正常志愿者99Tcm-HL91的生物学分布揭示,显像剂主要集中于腹部肝脏与肾脏,上半体摄取显像剂极少。心脏放射性计数下降极快,正常肺部几乎无放射性分布。1、2与4小时平面显像恶性肿瘤的T/NT值逐渐增高,4小时SPECT/CT断层显像,图像质量更优。23例肺癌与肺转移瘤病灶表现为对99Tcm-HL91明显摄取,全部显像阳性,灵敏性100.0%;5例良性病变显像,4例未摄取显像剂,呈显像阴性,特异性为80.0%;28例肺部良恶性病变99Tcm-HL91乏氧显像的符合率为96.0%。结论:99Tcm-HL91乏氧显像剂可满足肺癌与肺转移瘤诊断。SPECT/CT断层显像可进一步提高诊断效能。
Objective: To investigate the feasibility and effect of 99Tcm-HL91 hypoxia imaging in the diagnosis of lung cancer and pulmonary metastases. Methods: Six normal volunteers were selected for 99Tcm-HL91 whole body imaging. Twenty-eight patients with primary and secondary pulmonary malignancies and suspected tumors were subjected to 99Tcm-HL91 hypoxia imaging. SPECT / CT scintigraphy 4 hours after phase static imaging combined with intravenous injection of imaging agent. Results: The biological distribution of 99Tcm-HL91 in normal volunteers revealed that the imaging agent was mainly concentrated in the liver and kidney of the abdomen, and there were very few imaging agents in the upper half of the body. Cardiac radioactivity declines very quickly and there is almost no radiation distribution in normal lungs. The T / NT values of 1, 2 and 4-hour planar imaging malignant tumors gradually increased, and 4-hour SPECT / CT imaging showed better image quality. Twenty-three cases of lung cancer and lung metastases showed significant uptake of 99Tcm-HL91, all of them were positive, with a sensitivity of 100.0%. Five cases of benign lesions and four cases of non-imaging agents showed negative imaging with specificity of 80.0%. The coincidence rate of 99Tcm-HL91 hypoxia imaging in 28 cases of benign and malignant pulmonary lesions was 96.0%. Conclusion: 99Tcm-HL91 hypoxia imaging agent can be used to diagnose lung cancer and lung metastases. SPECT / CT tomography can further improve diagnostic performance.