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目的 :对比观察阿霉素 (ADM)多相脂质体与游离 ADM治疗晚期肝癌近期疗效及副作用。方法 :131例晚期肝癌患者 ,随机分成两组 ,A组为 ADM多相脂质体介入化疗组 (治疗组 ) ,B组为游离 ADM介入化疗组(对照组 )。结果 :平均生存期 1a生存率两组无明显差别 ,近期疗效 A组优于 B组 ,毒副作用 A组较 B组轻。结论 :两种治疗方法平均生存期无明显差异 ,ADM多相脂质体介入化疗可提高近期疗效 ,降低毒副作用 ,提高患者生活质量
Objective: To compare the short-term curative effect and side effects of adriamycin (ADM) multi-phase liposomes and free ADM in the treatment of advanced liver cancer. Methods: One hundred and thirty-one patients with advanced hepatocellular carcinoma were randomly divided into two groups. Group A was treated with ADM multiphase liposomes (treatment group), group B was treated with free ADM (control group). Results: The average survival rate of 1a survival rate was no significant difference between the two groups, the recent efficacy of A group was better than the B group, toxic side effects of A group lighter than the B group. Conclusion: The average survival time of the two treatment methods was no significant difference, ADM multiphase liposome intervention chemotherapy can improve the short-term efficacy, reduce side effects, improve patient quality of life