近今的实验研究证明,对小鼠长期大剂量灭滴灵(MTZ)治疗,有潜在致癌作用,能增加小鼠自发性肺肿瘤和恶性淋巴瘤的发生率。在细菌中,MTZ及其代谢物县有使基因突变的活性,但对人类淋巴细胞则无基因毒性效应。因此,有关MTZ对人类的安全性,迄今尚有争议。Sloan等报道,喂饲MTZ能使1,2-二甲基肼 Recent experimental studies have demonstrated that mice treated with long-term high-dose metronidazole (MTZ) have a potential carcinogenic effect and can increase the incidence of spontaneous lung tumors and malignant lymphomas in mice. In bacteria, MTZ and its metabolites have mutated gene activity, but they have no genotoxic effect on human lymphocytes. Therefore, there is still controversy about the safety of MTZ to humans. Sloan et al. reported that feeding MTZ can make 1,2-dimethylhydrazine