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目的探讨银杏达莫注射液治疗急性脑梗死患者的临床疗效及其对血液流变学的影响。方法将100例急性脑梗死患者进行随机分成两组,对照组50例给予血塞通注射液,10 ml银杏叶提取物注射液加入500 ml 0.9%氯化钠注射液中静脉点滴,每天1次,疗程为2周;观察组50例给予银杏达莫注射液20 ml加入500 ml 0.9%氯化钠注射液中静脉点滴,每天1次,疗程为2周。治疗后对两组患者进行神经功能缺损评分,观察两组临床疗效比较两组治疗前后的血流变指标情况。结果两组治疗后观察组患者基本痊愈19例,基本痊愈率为38.0%,总有效率为92.0%;对照组患者基本痊愈12例,基本痊愈率为24.0%,显效率为76.0%,两组疗效比较差异有统计学意义(均P<0.05),血流变学指标两组较治疗前均明显降低,其中血浆黏度、全血黏度计纤维蛋白原含量的治疗效果均明显优于对照组。两组比较差异均有统计学意义(均P<0.05)。结论银杏达莫注射液治疗急性脑梗死,可以有效的改善血液的高粘状态从而改善脑血流量,保护神经功能和脑组织,临床效果显著,不良反应小。
Objective To investigate the clinical efficacy of Yinxingdamo injection in patients with acute cerebral infarction and its effect on hemorrheology. Methods 100 patients with acute cerebral infarction were randomly divided into two groups, the control group of 50 patients given Xuesaitong injection, 10 ml of Ginkgo biloba extract injection added 500 ml 0.9% sodium chloride injection intravenously once daily , Treatment for 2 weeks; observation group 50 cases given gingko Damo injection 20 ml added 500 ml 0.9% sodium chloride injection intravenously once a day for 2 weeks. After treatment, the neurological deficit scores of the two groups of patients were observed. The clinical curative effect of the two groups was observed and compared before and after treatment. Results After treatment, the patients in the observation group were basically cured in 19 cases, the basic cure rate was 38.0%, the total effective rate was 92.0%; the control group patients basically recovered in 12 cases, the basic cure rate was 24.0%, the effective rate was 76.0% There was significant difference between the two groups (all P <0.05). The indexes of hemorheology were significantly lower than those before treatment, and the therapeutic effect of plasma viscosity and whole blood viscidity fibrinogen were significantly better than those of the control group. The differences between the two groups were statistically significant (P <0.05). Conclusion Yin Xing Damo injection for the treatment of acute cerebral infarction, can effectively improve the high viscous state of the blood to improve cerebral blood flow, protect neurological function and brain tissue, the clinical effect is significant, adverse reactions.