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目的:探讨短期胰岛素强化治疗对初诊2型糖尿病胰岛β细胞功能影响。方法:选取我院2010年1月～2012年1月初诊2型糖尿病患者33例,胰岛素强化治疗2～3周,停用胰岛素,3个月后比较治疗前后血糖、血脂、糖化血红蛋白、胰岛素水平。结果:短期素强化治疗后患者血糖、血脂、糖化血红蛋白蛋白较治疗前明显下降,血浆胰岛素水平较治疗前比显著改善,差异有统计学意义(P<0.05)。3个月后随访:22例(66.67%)仅需饮食运动控制血糖可达标;11例(33.33%)需口服降糖药物血糖可达标。结论:短期胰岛素强化治疗可改善初诊2型糖尿病患者胰岛素β细胞功能,逆转部分2型糖尿病患者的病程,有效预防及延缓并发症的发生。
Objective: To investigate the effect of short-term intensive insulin therapy on pancreatic β-cell function in newly diagnosed type 2 diabetic patients. Methods: Thirty-three newly diagnosed type 2 diabetic patients in our hospital from January 2010 to January 2012 were enrolled in this study. Insulin was intensively treated for 2 to 3 weeks. Insulin was withdrawn. Blood glucose, blood lipid, glycosylated hemoglobin and insulin levels were compared before and after treatment three months later . Results: The levels of blood glucose, blood lipids and HbA1c in patients after intensive treatment were significantly lower than those before treatment, and the plasma insulin levels were significantly improved compared with before treatment (P <0.05). Follow-up after 3 months: 22 cases (66.67%) only had to control their blood glucose by dietary exercise control; 11 cases (33.33%) needed oral hypoglycemic drugs to reach the standard of blood glucose. Conclusion: Short-term intensive insulin therapy can improve insulin β-cell function in newly diagnosed type 2 diabetic patients and reverse the course of some type 2 diabetes mellitus patients, effectively preventing and slowing the occurrence of complications.