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目的 观察血红素氧合酶 1(HO 1)在不稳定型心绞痛患者中的表达。方法 将经冠脉造影确诊的不稳定型心绞痛患者 5 2例作为研究对象试验组 ,选择冠脉造影确诊的稳定型心绞痛患者 5 0例作为研究对象对照组。利用免疫组化方法和Westernblot检测心绞痛患者外周血单个核细胞中HO 1的表达水平。结果 不稳定型心绞痛患者HO 1表达明显高于稳定型心绞痛患者 (P <0 0 1)。结论 HO 1的表达水平与心绞痛类型有关。
Objective To observe the expression of heme oxygenase 1 (HO 1) in patients with unstable angina pectoris. Methods Fifty-two patients with unstable angina pectoris confirmed by coronary angiography were selected as the experimental group. Fifty patients with stable angina pectoris diagnosed by coronary angiography were selected as the control group. The expression of HO 1 in peripheral blood mononuclear cells of patients with angina pectoris was detected by immunohistochemistry and Western blot. Results HO1 expression in patients with unstable angina was significantly higher than that in patients with stable angina (P <0.01). Conclusions The expression level of HO 1 is related to the type of angina pectoris.