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目的分析深圳市诺如病毒感染的流行特征,为制定预防与控制策略提供科学依据。方法对深圳市疾病控制信息管理系统2005～2007年诺如病毒感染性腹泻暴发疫情资料进行流行病学分析;收集2008年深圳市感染性腹泻病原谱哨点监测和福田区婴幼儿非细菌性腹泻病原谱哨点监测样本共779份应用RT-PCR方法检测诺如病毒核酸。结果诺如病毒是深圳市2005-2007年其他感染性腹泻暴发疫情的主要病原,占其他感染性腹泻暴发疫情总宗数的84.61%。深圳市感染性腹泻病原谱哨点监测结果显示,诺如病毒还是非细菌性腹泻的重要病原,在全人群组非细菌性腹泻病毒病原的检测中阳性率达24.69%,高于轮状病毒感染的15.76%。但在婴幼儿非细菌性感染性腹泻病原谱监测中,诺如病毒检出阳性率为16.83%,低于轮状病毒感染的55.77%。诺如病毒性腹泻暴发的高峰在10、11、12、1月,与诺如病毒性腹泻散发的高峰11、1月重合性较好,提示两者存在关联性。结论控制诺如病毒感染对降低法定传染病发病数,防控公共卫生应急事件具有重要意义。
Objective To analyze the epidemiological characteristics of Norovirus infection in Shenzhen and to provide a scientific basis for the formulation of prevention and control strategies. Methods Epidemiological data of epidemic situation of Norovirus infectious diarrhea in Shenzhen Disease Control Information Management System from 2005 to 2007 were collected. The surveillance of sentinel surveillance of infectious diarrhea in Shenzhen and non-bacterial infant diarrhea in Futian District A total of 779 samples of the sentinel surveillance samples were used to detect Norovirus nucleic acid by RT-PCR. Results Norovirus was the major cause of other outbreaks of infectious diarrhea in Shenzhen in 2005-2007, accounting for 84.61% of the total number of other infectious diarrhea outbreaks. Norovirus was also an important pathogen of non-bacterial diarrhea. The positive rate of non-bacterial diarrhea virus in the whole population was 24.69%, higher than that of rotavirus 15.76% of infections. However, the detection rate of Norovirus was 16.83%, which was 55.77% less than that of rotavirus in the surveillance of infant and non-bacterial infectious diarrhea. The peak of Norovirus viral diarrhea outbreaks coincided with the peak of norovirus viral diarrhea in January, January and January at 10, 11, 12 and January, suggesting a correlation between the two. Conclusion Control of norovirus infection is of great importance in reducing the incidence of statutory infectious diseases and preventing public health emergencies.