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作者为103例冠脉造影病人作了血清脂蛋白测定以分析冠脉狭窄病变(冠脉病变)与血清脂蛋白亚型及其他易患因素的关系。造影提示冠脉正常者47例,男32,女15。平均年龄55±7岁。造影提示冠脉有不同程度病变者56例,男50,女6。平均年龄58±9岁。多因素逐步回归分析的结果表明不论是病变支数或病变严重度均与血清HDL_2-C呈负相关,与血清LDL-C呈正相关,如结合其他易患因素进行分析,则增加与年龄、吸烟呈正相关。上述结果提示随着年龄增长,吸烟及血清中HDL_2-C降低和LDL-C增高将促使和增加冠脉粥样硬化病变的发生和发展。
The authors performed a serum lipoprotein assay in 103 patients with coronary angiography to analyze the relationship between coronary artery stenosis (coronary lesions) and serum lipoprotein subtypes and other predisposing factors. Angiography prompted normal coronary artery in 47 cases, male 32, female 15. The average age of 55 ± 7 years old. Angiography prompted different degrees of coronary lesions in 56 cases, 50 men and 6 women. The average age of 58 ± 9 years old. The results of stepwise multiple regression analysis showed that both the lesion count and lesion severity were negatively correlated with serum HDL-C and positively correlated with serum LDL-C. If analyzed in combination with other predisposing factors, the association with age, smoking Was positively correlated. These results suggest that with age, smoking and serum HDL 2-C decreased and elevated LDL-C will promote and increase the incidence of coronary atherosclerosis and development.