药物致死量的测定是药学研究中不可缺少的一项工作,有关这方面的文献国内外曾有很多报道。目前在国内各单位均分别应用着一种测定方法,但究竟哪一种方法较为简单实用,各有不同的评价。鉴于药物致死量的测定是评定药物毒性及为临床试用新药时确定适宜治疗剂量的一个重要环节,因而虽是一个老问题,仍有讨论的必要。有关测定药物致死量时动物的选择、分组、动物种屬以及观察时间等问题,我们 The determination of lethal dose is an indispensable task in pharmaceutical research. There have been many reports at home and abroad concerning the literature about this aspect. At present, all the units in China are applied with a measurement method, but which method is more simple and practical, each with different evaluations. In view of the fact that the determination of the lethal dose of a drug is an important part of assessing the toxicity of drugs and of determining the appropriate therapeutic dose for clinical trial of new drugs, there is still a need for discussion although it is an old problem. For the determination of animal lethal dose selection, grouping, animal species and observation time and other issues, we