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目的探讨滋阴补阳方序贯法联合氯米芬(CC)/人绝经期促性腺激素(HMG)/人绒毛膜促性腺激素(HCG)治疗日节律紊乱兼排卵障碍性不孕症的临床疗效。方法回顾性分析75例日节律紊乱兼排卵障碍性不孕症患者114个促排卵周期的临床资料,根据不同治疗方案分为试验组(39例)和对照组(36例),试验组患者予滋阴补阳方序贯法联合CC/HMG/HCG 61个促排卵周期治疗,对照组患者予CC/HMG/HCG 53个促排卵周期治疗。观察两组患者周期排卵率、单卵泡排卵率、卵泡输出率、促排卵天数、卵巢过度刺激综合征(OHSS)发生率、注射HCG日子宫内膜厚度及形态、各组未破裂黄素化综合征(LUFS)率、周期妊娠率、周期流产率、周期双胎妊娠率。结果试验组的卵泡输出率、注射HCG日内膜厚度以及周期妊娠率较对照组高,差异有统计学意义(P<0.05)。试验组与对照组之间周期排卵率、单卵泡排卵率、促排卵天数、LUFS率、OHSS率、周期流产率、注射HCG日A级内膜率、周期双胎妊娠率差异无统计学意义。结论日节律紊乱兼排卵障碍性不孕症患者选择滋阴补阳序贯法联合CC/HMG/HCG促排卵能改善子宫内膜容受性,提高妊娠率。
Objective To investigate the clinical effects of sequential therapy of nourishing yin and yang recipe combined with clomiphene citrate (CC) / human menopausal gonadotropin (HMG) / human chorionic gonadotropin (HCG) on rhythm disorders and anovulatory infertility. Methods A retrospective analysis of clinical data of 114 ovulation cycles in 75 patients with dyskinesia of both rhythms and anovulation was made. According to the different treatment regimens, the patients were divided into experimental group (39 cases) and control group (36 cases). The patients in experimental group Ziyin Buyang sequential method combined CC / HMG / HCG 61 ovulation cycle treatment, control group of patients with CC / HMG / HCG 53 ovulation cycle treatment. The ovulation rate, single ovulation rate, follicular output rate, ovulation induction days, the incidence of ovarian hyperstimulation syndrome (OHSS), endometrial thickness and morphology at HCG injection were observed in two groups, and the unruptured luteinizing syndrome LUFS rate, cycle pregnancy rate, cycle miscarriage rate, cycle twin pregnancy rate. Results The follicular output rate, HCG intima-media thickness and cycle pregnancy rate in the experimental group were significantly higher than those in the control group (P <0.05). The ovulation rate, ovulation rate, ovulation induction days, LUFS rate, OHSS rate, periodic miscarriage rate, grade A endometrial injection rate on HCG day, and the rate of twin pregnancy were not significantly different between the experimental group and the control group. CONCLUSIONS: Day rhythm disorder and ovulation disorder infertility patients choose Yin and Yang sequential method combined with CC / HMG / HCG ovulation can improve endometrial receptivity and improve pregnancy rate.