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目的检测多发性肌炎(PM)和皮肌炎(DM)、狼疮肾炎(LN)、类风湿关节炎(RA)患者血清中IL-18水平,比较活动期和非活动期IL-18水平,以探讨IL-18与疾病活动相关性。方法采用酶联免疫吸附法(ELISA)测定。研究对象包括PM/DM、LN和RA患者各30例,正常对照者30例。结果 PM/DM、LN、RA患者血清IL-18水平比正常对照组明显升高,三种不同疾病活动期血清中IL-18水平明显高于各自非活动期。结论 IL-18在PM/DM、LN、RA患者血清中明显升高,浓度与疾病活动性呈正相关。
Objective To detect the serum level of IL-18 in patients with polymyositis (PM), dermatomyositis (DM), lupus nephritis (LN) and rheumatoid arthritis (RA). To compare the levels of IL-18 in active and inactive phases, To investigate the IL-18 and disease activity. Methods The enzyme-linked immunosorbent assay (ELISA) was used. The study included 30 cases of PM / DM, LN and RA, and 30 cases of normal control. Results Serum levels of IL-18 in patients with PM, DM, LN and RA were significantly higher than those in normal controls. The levels of IL-18 in active phases of three different diseases were significantly higher than those in inactive periods. Conclusion IL-18 is significantly increased in serum of patients with PM / DM, LN and RA, and the concentration of IL-18 is positively correlated with disease activity.