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目的研究替米沙坦对尿白蛋白排泄率(UAER)正常的DM患者肾小球滤过率(GFR)的影响。方法 113例UAER正常的DM患者,口服替米沙坦40mg/d,9～14周,分析治疗前后GFR的变化。结果治疗前DM组的GFR高于对照组(P<0.01);治疗后DM组GFR较治疗前降低(P<0.01);治疗后GFR下降者治疗前的GFR高于非下降者。结论替米沙坦能有效改善UAER正常的DM患者的高GFR状态,对DM患者的肾脏有保护作用。
Objective To investigate the effect of telmisartan on glomerular filtration rate (GFR) in patients with normal urinary albumin excretion (UAER). Methods 113 patients with normal UAER DM were treated with telmisartan 40 mg / d for 9-14 weeks. The changes of GFR before and after treatment were analyzed. Results The GFR of DM group before treatment was significantly higher than that of control group (P <0.01). The GFR of DM group was lower than that before treatment (P <0.01) after treatment. Conclusion Telmisartan can effectively improve the high GFR status of DM patients with normal UAER and protect the kidney of DM patients.