激肽是生物活性多肽基在酶的作用下形成,是激肽原成为血管舒缓素的激活剂与作用于组织的激素。极小剂量可引起机体的一系列生理效应:(1)使支气管、肠、子宫平滑肌收缩;(2)使动脉扩张引起低血压、毛细血管渗透性增高、短暂血容量增加,并对血流变学特性有一定作用;(3)影响疼痛反应;(4)刺激血球渗出;(5)对神经系统作用。大脑皮层中激肽原的浓度比小脑与脑干中低3倍,而激肽酶的活性较高。一、激肽对实验动物的反应:与实验动物的种类和激肽的剂量有关。在动物脑室内注入激肽时可出现运动不安,以后抑制、低血压、心搏徐缓、EKG改变、呼吸急促、瞳孔缩小、多涎、意向震颤和痉挛等。此可能为阻滞胆硷能与肾上腺素能系统所 Kinin is a bioactive polypeptide based on the role of the enzyme is formed, is a kininogen kygestatin as activator and role in the organization of hormones. Very small dose can cause a series of physiological effects of the body: (1) the bronchial, intestine, uterine smooth muscle contraction; (2) the arterial dilatation caused by hypotension, capillary permeability increased transient blood volume increased, and blood rheology Learning characteristics have a role; (3) affect the pain response; (4) stimulate blood cell exudation; (5) on the nervous system. The concentration of kininogen in the cerebral cortex is three times lower than in the cerebellum and the brainstem, whereas the kinase activity is higher. First, the response of kinin to experimental animals: the type of experimental animals and the dose of kinin. In animal intraventricular injection of kinin may appear uneasy movement, after inhibition, hypotension, bradycardia, EKG changes, shortness of breath, miosis, polygia, tremor and spasms of intention. This may block the cholinergic and adrenergic systems