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川楝素(TS)浓度依赖性地使快反应电位复极至90％的时程(APD_(90)延长。用BaCl_2阻断I_(kl),可取消TS延长APD_(90)的作用.TS使慢反应电位的APD延长和收缩力(FC)增强。用BaCl_2后,可取消TS的上述作用。CdCI_2取消TS增强FC的作用,但延长APD的作用存在。提示,TS抑制I_(kl),其正性肌力作用是继发于APD的延长及钙通道的失活减慢。
Toosendanin (TS) prolonged APD_ (90) in a concentration-dependent manner and repolarization potential of 90% (APD_ (90)). The prolongation of APD and the increase of contractile force (FC) of slow response potentials can eliminate the above effects of TS with BaCl 2 .CdCI_2 cancels the effect of TS on the enhancement of FC but prolongs the action of APD, suggesting that TS suppresses I_ (kl), Its positive inotropic effect is secondary to prolonged APD and slower calcium channel inactivation.