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目的观察比较抗生素不同给药方案对妊娠期糖尿病患者剖宫产术后预防感染的临床疗效。方法 120例行剖宫产术的妊娠期糖尿病患者随机分成研究组及对照组各60例,在新生儿断脐后静脉滴注抗生素的基础上,研究组术后6 h再追加抗生素1次,对照组继续静脉使用抗生素预防感染至术后48 h。结果研究组和对照组的有效率分别为93.4%和96.7%,WBC<12×109/L平均天数为(3.4±1.5)d和(2.9±1.4)d,无发热及术后低热并于48 h内恢复正常的分别为58例及59例,研究组切口甲级愈合56例,乙级愈合(硬结)4例,对照组切口甲级愈合58例,乙级愈合(硬结)2例,切口均无丙级愈合,两组有效率、生理病理指标、切口愈合情况比较差异均无统计学意义(P>0.05)。结论术后经静脉追加1次抗生素的预防方案在妊娠期糖尿病患者剖宫产术后预防感染的效果与传统的术后连续使用抗生素2 d的效果相仿,且具有经济、减少细菌耐药性产生的优点,值得临床推广应用。
Objective To compare the clinical efficacy of different antibiotic dosage regimens in preventing post-cesarean section infection in gestational diabetes mellitus patients. Methods One hundred and twenty cases of gestational diabetes mellitus with cesarean section were randomly divided into study group (60 cases) and control group (60 cases). On the basis of neonatal intravenous infusion of umbilical vein, the study group was given additional antibiotics The control group continued intravenous antibiotics to prevent infection to 48 h after surgery. Results The effective rates of the study group and the control group were 93.4% and 96.7%, respectively. The mean days of WBC <12 × 109 / L were (3.4 ± 1.5) days and (2.9 ± 1.4) days, with no fever and postoperative fever. h in 58 cases and 59 cases, respectively. The study group had 56 cases of grade A healed incision, 4 cases of grade B healed (induration), 58 cases of grade A healed in control group, 2 cases of grade B healed (induration) There was no grade C healing. There was no significant difference between the two groups in the efficiency, physiology and pathology, incision healing (P> 0.05). Conclusions The prophylactic regimen of antibiotics supplemented with intravenous once after operation is effective in preventing infection after cesarean section in patients with gestational diabetes mellitus, which is similar to the traditional continuous antibiotic 2 d after operation and has the advantages of economy and reduced bacterial resistance The advantages of clinical application is worth.