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目的 :以盐酸异丙嗪 - β环糊精 (PMH - βCD)为主药制备干糖浆。方法 :以PMH - βCD为原料 ,采用均匀设计法 ,选择糖粉、葡萄糖、维生素C为因素 ,吸湿率、薄层层析为考察指标 ,并以紫外分光光度法检测含量 ,优化制剂的处方。结果 :得出最佳处方工艺 ,A =6 2 .0 ,B =6 .2 0 ,C =0 .16 ,吸湿率为 0 .3192。结论 :以PMH - βCD为主药的干糖浆与PMH为主药的干糖浆相对吸湿率降低 ,稳定性提高
Objective: To prepare dry syrup with promethazine hydrochloride - β - cyclodextrin (PMH - βCD) as the main drug. Methods: Using PMH - βCD as raw material, uniform design method, sugar powder, glucose and vitamin C as factors, moisture absorption rate and TLC were used as indexes. The content of PMH - βCD was determined by UV spectrophotometry to optimize preparation prescription. Results: The best prescription process was obtained, A = 62.0, B = 6.2. 0, C = 0.16, and the moisture absorption rate was 0.3192. Conclusion: The relative hygroscopicity of dry syrup with PMH - βCD as the main drug and dry syrup with PMH as the main drug is decreased and its stability is improved