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目的:研究B7-H4在T1期肾癌组织中的表达及其评估预后的价值。方法:检测并统计102例肾癌标本中B7-H4的表达率、肾癌患者临床特征及术后复发率等。结果:B7-H4表达阳性及阴性组在临床及病理特征方面无统计学差异;无瘤生存率和转移率方面阳性组明显高于阴性组,具有统计学差异;多变量分析中,肾癌术后复发方面,肿瘤大小、临床分期及B7-H4阳性表达具有显著相关性(P<0.05)。结论:B7-H4的表达与肾透明细胞癌的发生发展及免疫逃避密切相关,在评估肾癌患者预后方面具有一定价值。
Objective: To study the expression of B7-H4 in T1 stage renal cell carcinoma and its value of prognosis. Methods: The expression of B7-H4 in 102 cases of renal cell carcinoma was detected and statistically analyzed. The clinical features, recurrence rate and so on of patients with renal cell carcinoma were detected. Results: There was no significant difference in the clinical and pathological features between positive and negative B7-H4 expression groups. The positive rates of tumor-free survival and metastasis were significantly higher in the positive group than in the negative group, with statistical significance. In the multivariate analysis, In terms of recurrence, tumor size, clinical stage and positive expression of B7-H4 were significantly correlated (P <0.05). Conclusion: The expression of B7-H4 is closely related to the occurrence and development of renal clear cell carcinoma and immune evasion. It is of great value in evaluating the prognosis of patients with renal cell carcinoma.