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目的 评价对氨基水杨酸钠和力克肺疾序贯疗法治疗复治耐药肺结核的疗效。方法 5 9例复发和耐药结核病人 (男性30名 ,女性 2 9名 )在起初 3个月内两组均给予 AKHP静脉滴注和 VTh(z)口服治疗 ;序贯治疗组的 30名病人在 6个月的巩固期内给予 DVTh(Z)口服 ,而对照组则给予 EVTh(Z)。结果 治疗 9个月后 ,序贯治疗组痰菌涂片、培养阴转率明显高于对照组 (P<0 .0 5 ) ;其病灶吸收率、空洞闭合和缩小率也均高于对照组。结论 对氨基水杨酸钠 /力克肺疾序贯疗法治疗复治耐药肺结核是较理想的方案之一。
Objective To evaluate the efficacy of Sodium Aminosalicylate and Lectra sequential therapy in the treatment of refractory pulmonary tuberculosis. METHODS: Ninety-nine relapsed and drug-resistant TB patients (30 males and 29 females) received intravenous AKHP and VTh (z) orally in both groups within the first 3 months; 30 patients in the sequential treatment group DVTh (Z) was given orally during the 6-month consolidation period while the control group was given EVTh (Z). Results After 9 months of treatment, sputum bacterial smear and culture negative conversion rate in the sequential treatment group were significantly higher than those in the control group (P0.05), and the rates of lesion absorption, voids closure and reduction were also higher than those in the control group . Conclusion Sodium aminosalicylate / Lectra pulmonary disease sequential therapy for re-treatment of resistant pulmonary tuberculosis is one of the more ideal program.