本文报告1例由于食入红棕榈油发生高胡萝卜素血症所致掌跖皮肤桔黄色色素沉着,并讨论了皮肤变黄的鉴别诊断。患者男性,29岁。掌跖桔黄色色素沉着多年,巩膜无黄染。其母及兄弟姐妹掌跖部有类似发病,家庭成员食含高红棕榈的饮食。患者血胡萝卜素水平升高达229μg/dl(正常50～200μg/dl)而血总胆红素正常。 作者指出:皮肤变黄的原因很多,最常见于高胆红素血症,也可见于高胡萝卜素血症。两者鉴别在 This article reports 1 case of orange-yellow pigmentation of the palms of the plantar skin due to hypercarotenemia due to the ingestion of red palm oil and discusses the differential diagnosis of yellowing of the skin. Patient male, 29 years old. Palmar plantar yellow pigmentation for many years, Sclera no yellow dye. Their mother and siblings had similar onset of palms and soles, and family members fed a diet containing high red palm. Patients with elevated carotenoid levels up to 229μg / dl (normal 50 ~ 200μg / dl) and blood total bilirubin normal. The authors point out that there are many reasons for the yellowing of the skin, most commonly hyperbilirubinemia and also hyperglycemia. The two identified in