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目的 观察高渗氯化钠羟乙基淀粉 4 0注射液 (HypertonicSodiumChlorideHydroexythlstarch 4 0injection ,简称“复方高渗液”)Ⅱ期临床试验中的抗失血性休克效果。方法 选择创伤性失血性休克病人 1 5例 ,收缩压均低于 90mmHg。“复方高渗液”的输入速度 1 2 5～ 2 5mL/min ,平均 1 6 6 7mL/min。结果 输入后 4～ 5min血压即开始上升。至用药结束 ,休克病人的血压明显升高 (P <0 0 1 ) ,收缩压、舒张压的平均增幅分别为 (31 31± 9 91 )mmHg及 (9 6 2± 7 98)mmHg ;心律及呼吸也有明显改善 (P <0 0 5 ) ;病人的尿量达 (2 1 4± 1 1 2 )mL·kg-1 ·h-1 。病人平均用药量 (393 0 8± 1 0 5 4 7)mL。平均给药时间(2 3 0 8± 5 2 2 )min。观察 2 4h ,未见有不良事件发生。结论 “复方高渗液”具有良好的抗失血性休克的作用
Objective To observe the anti-hemorrhagic shock effect of hypertonic sodium chloride Hydroxyethyl starch 40 injection (Phase II) in Phase II clinical trial. Methods Fifteen patients with traumatic hemorrhagic shock were selected, systolic blood pressure was lower than 90mmHg. The infusion rate of compound hypertonic solution was 125 ~ 250mL / min with an average of 16667mL / min. 4 ~ 5min after the results entered the blood pressure began to rise. At the end of treatment, the blood pressure of shock patients was significantly increased (P <0.01), and the average increase of systolic and diastolic blood pressure was (31 31 ± 9 91) mmHg and (96 2 ± 7 98) mmHg, respectively; Breathing was also significantly improved (P <0.05). The patient’s urine output was (21.4 ± 11.2) mL · kg-1 · h-1. The average patient medication (393 0 8 ± 1 0 5 4 7) mL. The average administration time (2380 ± 5222) min. Observation 24 h, no adverse events occurred. Conclusion “Compound hypertonic solution” has a good anti-hemorrhagic shock effect